Livedoid vasculitis - Livedoid Васкуліт
Livedoid Васкуліт (Livedoid vasculitis) - хранічнае скурнае захворванне, якое назіраецца пераважна ў жанчын маладога і сярэдняга ўзросту. Адзін з абрэвіятур, які выкарыстоўваецца для апісання яго прыкмет, - «Балючыя пурпурные язвы з сеткаватым малюнкам ніжніх канечнасцяў» (ФІЯЛЕТАВЫ). Гэта звязана з шэрагам захворванняў, у тым ліку хранічнай вянознай гіпертэнзіяй і варыкозам.
☆ У выніках Stiftung Warentest у Германіі ў 2022 годзе задаволенасць спажыўцоў ModelDerm была толькі крыху ніжэйшай, чым платнымі тэлемедыцынскімі кансультацыямі.
Гэта можа суправаджацца болем.
References
Livedoid vasculopathy - гэта рэдкае захворванне скуры, якое характарызуецца балючымі язвамі, якія пастаянна з'яўляюцца на галёнках.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy - гэта рэдкае захворванне скуры, якое выклікае перыядычныя язвы на галёнках, пакідаючы пасля сябе бледныя шнары, вядомыя як бледная атрафія. Хоць дакладная прычына да гэтага часу незразумелая, лічыцца, што павышаная згусальнасць крыві (hypercoagulability) з'яўляецца асноўным фактарам, а запаленне адыгрывае другарадную ролю. Фактары, якія спрыяюць згусальнасці, ўключаюць наступныя - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. У біяпсіі стан паказвае тромбы ўнутры сасудаў, патаўшчэнне сценак сасудаў і рубцы. Лячэнне ўключае ў сябе шматбаковы падыход, які засяроджваецца на прадухіленні адукацыі тромбаў з дапамогай такіх лекаў, як антыагреганты, разрэджвальнікі крыві і фібрыналітычная тэрапія. Пры гэтым захворванні скуры можна выкарыстоўваць розныя прэпараты - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy - гэта рэдкае захворванне, пры якім паразы ўзнікаюць на абедзвюх нагах. Мяркуецца, што ўтварэнне тромбаў у дробных крывяносных сасудах адбываецца з-за павышэння згусальнасці і памяншэння распаду тромбаў, а таксама пашкоджання слізістай абалонкі сасудаў. Гэта часцей сустракаецца ў жанчын, асабліва ва ўзросце ад 15 да 50 гадоў. Адмова ад курэння, догляд за ранамі і выкарыстанне такіх лекаў, як сродкі для разрэджвання крыві і антыагреганты, аказаліся эфектыўнымі.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
